The manufacturing of effervescent tablets

They were discovered in AGEN, Lot-et-Garonne, in 1935. Radiologist Camille BRU observed the digestive system and found that effervescence played a role in digestion.

He developed the first gaseous remedy for heartburn and founded his pharmaceutical laboratory UPSA to market his revolutionary pastilles. In the 60s, his son Jean BRU incorporated aspirin, then paracetamol. The company thus became a pioneer in effervescent medicines.

An effervescent tablet is one designed to fragment on contact with water and dissolve rapidly as a result of the rapid release of carbon dioxide (CO2). The carbon dioxide produced by an acid-base reaction between an organic acid and a carbonate, both present in solid form in the tablet, causes the tablet to effervesce (by the rapid appearance of gas bubbles in the liquid) and fragment, facilitating its dispersion and dissolution in the liquid.

Effervescence not only adds a pleasant sensory experience, but also facilitates nutrient consumption.

Once dissolved in water, the supplement is in a liquid form, which may be easier to swallow for people who have difficulty with traditional tablets or capsules. Effervescence creates a solution which generally contains smaller particles,

Effervescent tablet manufacturing : A Delicate Development

Mixing (with our mixing and manufacturing department)

The selected ingredients are weighed and then blended to achieve an even distribution of nutrients. We use special mixers and paddles to ensure perfect uniformity.

Wet granulation

Effervescent tablets are manufactured using a fluidized-bed granulation process.

The 3 operations - premixing the powders, triggering the effervescent reaction, blocking the reaction - are carried out in a single unit known as a granulator-dryer.

All these operations are carried out in rooms with controlled temperature and hygrometry to avoid uncontrolled effervescence.

Compression

The granules are then compressed to form solid tablets. We use compression machines that apply high pressure to compact the granules in specific molds. Tablets can be produced in a variety of shapes and sizes, according to your specifications.

As with wet granulation, this operation is carried out in rooms with controlled temperature and hygrometry to avoid uncontrolled effervescence.